Suplementos De Vitamina D

[cyberots 49]

do artigo: "Given that NSAIDs exert their actions by blocking COX and thus suppressing prostaglandin production, a theoretical rationale exists whereby these drugs may have detrimental effects on muscle regeneration and supercompensation"

Em sequencia...

"Based on current evidence, there is little reason to believe that the occasional use of NSAIDs will negatively affect muscle growth, although the efficacy for their use in alleviating inflammatory symptoms remains questionable. Evidence on the hypertrophic effects of the chronic use of NSAIDs is less clear. In those who are untrained, it does not appear that regular NSAID use will impede growth in the short term, and at least one study indicates that it may in fact have a positive impact."

[mpcosta82 2967]

Sim, mas note que o autor fala "a curto prazo" e "uso ocasional de NSAIDs".

Não há estudos de longo prazo correlacionando o uso de NSAIDs com hipertrofia muscular. Por isso que não dá para concluir, a partir dos estudos de curto-prazo, qual seria o efeito da inibição do COX-2 a longo prazo.

Por causa do efeito fisiológico da inibição do COX-2 por NSAIDs é de se esperar que, a longo prazo, exista algum detrimento, como o estudo conclui: "Given their reported impairment of satellite cell activity, however, longer-term NSAID use may well be detrimental, particularly in those who possess greater growth potential"

[cyberots 49]

Citando algumas coisas que achei rapidamente

The effects of vitamin D on skeletal muscle function and cellular signaling.

It is thought that every cell in the body expresses the vitamin D receptor, and therefore vitamin D may play a role in health and homeostasis of every organ system, including skeletal muscle. Human, animal, and cell culture studies have collectively shown that vitamin D affects muscle strength and function. Vitamin D functions in a plethora of cellular processes in skeletal muscle including calcium homeostasis, cell proliferation, cell differentiation, fiber size, prevention of fatty degeneration, protection against insulin resistance and arachidonic acid mobilization. These processes appear to be mediated by several signaling pathways affected by vitamin D. This review aims to explore the effects of vitamin D on skeletal muscle in each model system and to delineate potential cell signaling pathways affected by vitamin D.

http://www.ncbi.nlm....pubmed/21397021

Vitamin D and Its Role in Skeletal Muscle

Molecular mechanisms of vitamin D action in muscle tissue include genomic and non-genomic effects via a receptor present in muscle cells. Knockout mouse models of the vitamin D receptor provide insight into understanding the direct effects of vitamin D on muscle tissue. Vitamin D status is positively associated with physical performance and inversely associated with risk of falling. Vitamin D supplementation has been shown to improve tests of muscle performance, reduce falls, and possibly impact on muscle fiber composition and morphology in vitamin D deficient older adults.

http://www.ncbi.nlm....45/?tool=pubmed

Vitamin D and human skeletal muscle.

Vitamin D deficiency is an increasingly described phenomenon worldwide, with well-known impacts on calcium metabolism and bone health. Vitamin D has also been associated with chronic health problems such as bowel and colonic cancer, arthritis, diabetes and cardiovascular disease. In recent decades, there has been increased awareness of the impact of vitamin D on muscle morphology and function, but this is not well recognized in the Sports Medicine literature. In the early 20th century, athletes and coaches felt that ultraviolet rays had a positive impact on athletic performance, and increasingly, evidence is accumulating to support this view. Both cross-sectional and longitudinal studies allude to a functional role for vitamin D in muscle and more recently the discovery of the vitamin D receptor in muscle tissue provides a mechanistic understanding of the function of vitamin D within muscle. The identification of broad genomic and non-genomic roles for vitamin D within skeletal muscle has highlighted the potential impact vitamin D deficiency may have on both under-performance and the risk of injury in athletes. This review describes the current understanding of the role vitamin D plays within skeletal muscle tissue.

http://www.ncbi.nlm....pubmed/19807897

Vitamin D: extent of deficiency, effect on muscle function, bone health, performance, and injury prevention.

Vitamin D deficiencyis increasingly being identified in children, adolescents, and adults. Primary production of the active form of vitamin D occurs via a photolytic reaction induced by ultraviolet radiation B. Vitamin D has important effects on bone and muscle as well as on the immune system. Isolation ofa vitamin D receptor on muscle cells has been accompanied by studies showing receptor polymorphisms and age-related functional changeswhich have an effect on muscle performance. Insufficient levels havebeen associated with increased risk of stress fractures, decreased muscle performance, and increased sick days. Although there is still debate about the appropriate levels of vitamin D, studies have suggested a minimal level of 32 ng/ml. Supplementation serves as an inexpensive option associated with reduction in both morbidity and financial costs.

http://www.ncbi.nlm....pubmed/20945707

Vitamin D and skeletal muscle tissue and function.

This review aims to summarize current knowledge on the role of vitamin D in skeletal muscle tissue and function. Vitamin D deficiency can cause a myopathy of varying severity. Clinical studies have indicated that vitamin D status is positively associated with muscle strength and physical performance and inversely associated with risk of falling. Vitamin D supplementation has shown to improve tests of muscle function, reduce falls, and possibly impact on muscle fiber composition and morphology in vitamin D deficient older adults. Molecular mechanisms of vitamin D action on muscle tissue include genomic and non-genomic effects via a receptor present in muscle cells. Genomic effects are initiated by binding of 1,25-dihydroxyvitamin D [1,25(OH)(2)D] to its nuclear receptor, which results in changes in gene transcription of mRNA and subsequent protein synthesis. Non-genomic effects of vitamin D are rapid and mediated through a cell surface receptor. Knockout mouse models of the vitamin D receptor provide insight into understanding the direct effects of vitamin D on muscle tissue. Recently, VDR polymorphisms have been described to affect muscle function. Parathyroid hormone which is strongly linked with vitamin D status also may play a role in muscle function; however, distinguishing its role from that of vitamin D has yet to be fully clarified. Despite the enormous advances in recent decades, further research is needed to fully characterize the exact underlying mechanisms of vitamin D action on muscle tissue and to understand how these cellular changes translate into clinical improvements in physical performance.

http://www.ncbi.nlm....pubmed/18727936

http://www.ncbi.nlm....pubmed/20538161

Acho que muitas deles vão contra essa sua teoria então...

Editado Outubro 4, 2012 às 14:01 por cyberots

[mpcosta82 2967]

só para saber, qual é a minha teoria?

[Brunobyof 330]

TAmbém fiquei nessa dúvida kkkk

Pessoal, esse produto é bom? tem um CxB legal na opinião de vocês?

Vibrant Health, Vitamin D3, 4,000 IU, 100 Organitabs

U$ 11,16

Foi o que eu comprei. Nunca tomei Vit.D3 antes, então dei uma pesquisada sobre dosagens e tal, mas não conheço marcas nem preços. Vi que o Mpcosta postou um por $8,00

com 5.000 UI e o dobro de cápsulas do que eu ecomprei...fiquei me sentindo assaltado agora huahuahuah será que tem algo diferente, tipo a forma de apresentação da vitamina? Ou se é com VitD2+D3?

[mpcosta82 2967]

hahahaha

Aquele outro era só D3, Bruno. Nem adianta comprar D2.

D3 é algo bem estabelecido, tem um montão de marcas diferentes, aí o preço varia bastante.

Quando você comprar novamente eu sugiro que compre as de 5.000 ou 10.000 IU, são as que tem melhor custo x benefício (até onde eu sei as mais baratas são da doctor's best e healthy origins, coisa de 13-14 dólares o pote com 360 caps de 5000 IU). Aí se você quiser usar uma dosagem menor é só não tomar todos os dias.

abraços

[AugustoO 3]

Cyberots....

E quanto a toxidade, você já sentiu alguma coisa?

Obrigado pelas respostas!

Vou comprar minha D3 agora mesmo ^^

Vou tomar 10.000 IU divididos em 2 vezes no dia de 5.000 IU

No primeiro mês vou tomar apenas 5.000 IU pra começar, depois mantenho os 10.000 IU.

Ei Bruno,

Eu vou comprar esse aqui manolo, achei o cxb interessante :

Healthy Origins, Vitamin D3, 5,000 IU, 360 Softgels

ta custando 13 dollares no site " ticaracatica "

Não estou fazendo propaganda, apenas tentando ajudar!

[cyberots 49]

só para saber, qual é a minha teoria?

Ué a pesquisa que vc citou não sugere nada e nem sequer pesquisou nada ou concluiu algo rs Ainda afirma não existirem estudos a respeito, fez somente uma hipótese sobre uma classe de medicamentos... dê que vc quer que eu chame? :

Cyberots....

E quanto a toxidade, você já sentiu alguma coisa?

Obrigado pelas respostas!

Vou comprar minha D3 agora mesmo ^^

Vou tomar 10.000 IU divididos em 2 vezes no dia de 5.000 IU

No primeiro mês vou tomar apenas 5.000 IU pra começar, depois mantenho os 10.000 IU.

Ei Bruno,

Eu vou comprar esse aqui manolo, achei o cxb interessante :

Healthy Origins, Vitamin D3, 5,000 IU, 360 Softgels

ta custando 13 dollares no site " ticaracatica "

Não estou fazendo propaganda, apenas tentando ajudar!

Nunca tive problema nenhum não, pode tomar tranquilo... atualmente to tomando 20.000.

abraços

Editado Outubro 4, 2012 às 14:55 por cyberots

[AugustoO 3]

20.000IU .....Cacete, vai vira sayajin desse jeito ashudashudhas

Vlws parceiro!!!

[mpcosta82 2967]

Ué a pesquisa que vc citou não sugere nada e nem sequer pesquisou nada ou concluiu algo rs Ainda afirma não existirem estudos a respeito, fez somente uma hipótese sobre uma classe de medicamentos...

Exatamente, eu falei que não dá para concluir nada a respeito. Foi só um raciocínio lógico (do autor do estudo), que pode ou não estar certo.

Por isso eu estranhei você dizer que eu tenho uma "teoria"... como se eu estivesse dizendo "vitamina D reduz a hipertrofia muscular" ou algo do tipo.

Com relação ao estudo sobre NSAIDs, diz o autor que fez que uma revisão da literatura existente relacionando NSAIDs e hipertrofia. Se algum dia o fulltext ficar disponível, a gente vai poder saber a conclusão dele

abraços