Duvidas de Creatina, exames alterados da função renal

[Empz 0]

Estou tomando só creatina e meus exames deu tudo ok, porém minha creatinina deu 1,64mg%, onde a referencia é  Homens e Mulheres: 0.40 a 1.40 mg% e meu ESTIMATVA DO RITMO DE FILTRAÇÃO GLOMERULAR (MDRD) deu 49,57 onde a referencia é ADULTO OUTROS...............................Maior ou igual a 60 mL/min/1.73m°, devo parar de tomar ou preciso procurar um nefrologista?

[projetohuck2 4249]

Como está o consumo de agua ?

 

[Empz 0]

4l.

[krebz 3756]

Creatina até já foi investigado dar esse falso-positivo na creatinina mas realmente não causa danos renais.

 

https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0173-z#:~:text=In terms of performance%2C the,of increasing high-intensity exercise

 

With regard to the question of whether creatine has effect on renal function, a few case studies [249,250,251,252] reported that individuals purportedly taking creatine with or without other supplements presented with high creatinine levels and/or renal dysfunction [249,250,251]. Additionally, one study suggested that feeding rats with renal cystic disease 2 g/kg/d of creatine for 1 week (equivalent to 140 g/day for a 70 kg individual) and 0.4 g/kg/d (equivalent to 28 g/day for a 70 kg individual) for 4 weeks exacerbated disease progression. These reports prompted some concern that creatine supplementation may impair renal function [253,254,255,256] and prompted a number of researchers to examine the impact of creatine supplementation on renal function [22, 51, 85, 114, 156, 172, 243,244,245,246,247,248, 257,258,259]. For example, Ferreira and associates [260] reported that creatine feeding (2 g/kg/d for 10 weeks equivalent to 140 g/kg/d in a 70 kg person) had no effects on glomerular filtration rate and renal plasma flow in Wistar rats. Likewise, Baracho and colleagues [261] reported that Wistar rats fed 0, 0.5, 1, or 2 g/kg/d of creatine did not result in renal and/or hepatic toxicity. Poortmans and coworkers reported that ingesting 20 g/day of creatine for 5 days [243], and up to 10 g/day from 10 months to 5 years [257] had no effect on creatine clearance, glomerular filtration rate, tubular resorption, or glomerular membrane permeability compared to controls. Kreider et al. [22] reported that creatine supplementation (5–10 g/day for 21 months) had no significant effects on creatinine or creatinine clearance in American football players. Gualono and associates [262] reported that 12 weeks of creatine supplementation had no effects on kidney function in type 2 diabetic patients. Finally, creatine supplement has been used as a means of reducing homocysteine levels and/or improving patient outcomes in patients with renal disease [263,264,265] as well as ameliorating birth asphyxia related renal dysfunction in mice [228]. Moreover, long-term, high dose ingestion of creatine (up to 30 g/d for up to 5 years) in patient populations has not been associated with an increased incidence of renal dysfunction [23, 155, 156, 172]. While some have suggested that individuals with pre-existing renal disease consult with their physician prior to creatine supplementation in an abundance of caution, these studies and others have led researchers to conclude that there is no compelling evidence that creatine supplementation negatively affects renal function in healthy or clinical populations [5, 6, 22, 53, 259, 266, 267].

[ccrmatheus 183]

43 minutos atrás, krebz disse:

Creatina até já foi investigado dar esse falso-positivo na creatinina mas realmente não causa danos renais.

 

https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0173-z#:~:text=In terms of performance%2C the,of increasing high-intensity exercise

 

With regard to the question of whether creatine has effect on renal function, a few case studies [249,250,251,252] reported that individuals purportedly taking creatine with or without other supplements presented with high creatinine levels and/or renal dysfunction [249,250,251]. Additionally, one study suggested that feeding rats with renal cystic disease 2 g/kg/d of creatine for 1 week (equivalent to 140 g/day for a 70 kg individual) and 0.4 g/kg/d (equivalent to 28 g/day for a 70 kg individual) for 4 weeks exacerbated disease progression. These reports prompted some concern that creatine supplementation may impair renal function [253,254,255,256] and prompted a number of researchers to examine the impact of creatine supplementation on renal function [22, 51, 85, 114, 156, 172, 243,244,245,246,247,248, 257,258,259]. For example, Ferreira and associates [260] reported that creatine feeding (2 g/kg/d for 10 weeks equivalent to 140 g/kg/d in a 70 kg person) had no effects on glomerular filtration rate and renal plasma flow in Wistar rats. Likewise, Baracho and colleagues [261] reported that Wistar rats fed 0, 0.5, 1, or 2 g/kg/d of creatine did not result in renal and/or hepatic toxicity. Poortmans and coworkers reported that ingesting 20 g/day of creatine for 5 days [243], and up to 10 g/day from 10 months to 5 years [257] had no effect on creatine clearance, glomerular filtration rate, tubular resorption, or glomerular membrane permeability compared to controls. Kreider et al. [22] reported that creatine supplementation (5–10 g/day for 21 months) had no significant effects on creatinine or creatinine clearance in American football players. Gualono and associates [262] reported that 12 weeks of creatine supplementation had no effects on kidney function in type 2 diabetic patients. Finally, creatine supplement has been used as a means of reducing homocysteine levels and/or improving patient outcomes in patients with renal disease [263,264,265] as well as ameliorating birth asphyxia related renal dysfunction in mice [228]. Moreover, long-term, high dose ingestion of creatine (up to 30 g/d for up to 5 years) in patient populations has not been associated with an increased incidence of renal dysfunction [23, 155, 156, 172]. While some have suggested that individuals with pre-existing renal disease consult with their physician prior to creatine supplementation in an abundance of caution, these studies and others have led researchers to conclude that there is no compelling evidence that creatine supplementation negatively affects renal function in healthy or clinical populations [5, 6, 22, 53, 259, 266, 267].

Dá uma lida, está ótimo o artigo!

[kkmultes 588]

faltaram muitas informações suas pra falar algo mais concreto, idade peso altura, percentual de gordura....Se você se entope de proteína, e ainda usa Creatina vai vir mais alto mesmo, se você tem mais massa muscular também...  mas claro, sempre vale verificar , afinal pra que fazer exames se na incidência de um resultado você não faz nada a respeito... 

[Tazim 6]

Não se preocupe. É normal essa alteração.

A creatina não prejudica a função renal. É mito.

 

O que acontece é que 1,6 porcento da creatina que ingerimos, é transformada em CREATININA. Isso não significa que vc esteja com função renal comprometida. Creatinina é só um marcador usado nos laboratórios, por ser mais barato, mas isso não vai refletir na perda da função renal.

 

Nesse caso é melhor dosar usando o marcador CISTATINA C, aí seu médico vai saber interpretar se há alguma alteração renal.

Editado Fevereiro 5, 2021 às 20:03 por Tazim

[DACS 17]

Voltei hoje no angiologista que me disse pra parar um pouco com a creatina porque tanto a creatinina quanto a ureia deram altas, mas só o que vejo quando pesquiso é que não tem nada a ver. A creatinina tem a ver com o quanto você se exercita também e eu tenho feito muita coisa, 9 treinos por semana, atividades variadas. Ureia tem a ver com a quantidade de proteína e aí sim eu posso estar exagerando.

O artigo que o krebz citou fala em 28g de creatina por dia num indivíduo de 70kg, eu devo tomar 10% disso e sou um pouco mais pesado.

Curioso que o endocrinologista viu esses mesmos exames e não falou nada.

[Marcon99 2]

O que pode causar aumento da creatinina são Lesões musculares, inflamação da pele e dos músculos, queimaduras e certas doenças também podem levar a níveis altos de creatinina. Se o nível de creatinina aumentar após a suplementação de creatina, é, muito provavelmente, uma indicação de aumento da quantidade de creatina nos músculos. Uma vez que o corpo está armazenando mais creatina, a proporção de creatina e de fosfocreatina convertidas em creatinina também aumentará.